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Tag Archive: liquid concentrates

  1. Guidelines For Cleaning Pharmaceutical Processing Equipment

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    Cleaning pharmaceutical processing equipment is challenging. Cleaning methods, soils present, type of manufacturing equipment, surfaces cleaned, choice of cleaning detergent and temperature should all be considered when setting up a cleaning procedure. Cleaning validation methods are required. The entire cleaning process must be standardized and documented according to the FDA’s cGMP regulations.

    Why Clean Pharmaceutical Processing Equipment? 

    • Maintain product quality.
    • Remove all trace ingredients to prevent the transfer of ingredients from one product to the next. This is especially important when multiple products are produced on the same equipment.
    • Prevent equipment malfunctions that may lead to product contamination.
    • Provide a clean surface for disinfection. Surfaces cannot be properly sanitized or disinfected if they are not thoroughly cleaned first.
    • Comply with local and international standards and regulations to ensure consumer safety and avoid legal issues.
    • Increase plant performance and productivity by diminishing waste, maintaining equipment and preserving product quality.
    • Enhance worker safety by providing a clean working environment and smoothly functioning equipment.

    Establishing A Cleaning Procedure

    Federal Regulations

    Pharmaceutical manufacturers are required to set up a fully documented written cleaning procedure for each piece of processing equipment in compliance with FDA 21 CFR Part 211.67. Documentation should include:

    • Responsibility for equipment cleaning and maintenance
    • Cleaning and sanitization schedules
    • A detailed description of the cleaning procedure
    • Removal of previous batch identification
    • Protection of clean equipment
    • Inspection of equipment prior to use

    Manufacturers must outline each of these steps in detail to be sure that all processes are followed clearly and succinctly.

    Cleaning Procedures

    Federal regulations require a very specific description of each step of the cleaning procedure. The following details should be documented.

    • Frequency of cleaning – including time requirements between processing products and cleaning
    • Cleaning tools used – any sponges, brushes, scrapers, sprayers, wipes or equipment used to aid the cleaning process
    • Establishment and sequence of each cleaning step
    • Identification of each specific piece of equipment to be cleaned, including instructions for cleaning between batches of the same or different products
    • Cleaning method – clean-in-place (CIP) or clean-out-of-place (COP)
    • Detailed instructions for any required disassembly and re-assembly of equipment if COP methods are used. Instructions should specify the parts to be removed and any assembly aids used during this process.
    • Identification of all cleaning detergents and detailed instructions for their use. Usage instructions should include amounts, concentration, temperature, dwell time and application method.
    • Type of water – deionized, distilled or tap
    • Number of rinse steps required
    • Drying and storage guidelines
    • Instructions for visual inspection after cleaning
    • Cleaning validation methods

    How to Clean

    Several factors must be taken into consideration to set up an effective cleaning process and remain in compliance with federal regulations.

     Soils

    Soils found on pharmaceutical processing equipment may be traces of the various ingredients used in production or soils from the actual manufacturing process such as oil, grease, dust or minerals. Understanding the soils that are present will guide your choice of cleaning detergent.

    Gels, polyethylene glycol, oils, titanium dioxide, dyes, silicons, flavorings, petrolatum, paraffin, proteins, steroids, sugars, alcohol, stearates, and cornstarch are some of the typical foulants that are often found on pharmaceutical processing equipment.

    Each type of soil is unique and requires the proper detergent to thoroughly clean the surface. Choose a cleaner that will best attack the soils you are trying to remove. Alkaline cleaners are the best choice for cleaning soils such as gels, dyes and petrolatum, while citric acid based cleaners are better suited for removing titanium dioxide. Protein or starch-based soils may require the use of an enzyme cleaner. Use the table below to help match the most effective type of cleaner to each kind of soil.

    Type of Equipment

    Mixing tanks, tablet presses, capsule fillers, centrifuges, granulators, filling lines, mixers, conveyors, filters, fluid lines, batch process tanks, tubes and flasks all need to be thoroughly cleaned. The design of the equipment must be taken into consideration. By nature of its construction, some types of equipment will be more difficult to clean than others. Hidden parts and blind holes present unique challenges.

    Another important factor to consider is the how the equipment is used. Are you cleaning a dedicated production system or equipment that is used to produce a range of products? Processing equipment used to produce multiple products has a greater chance of cross contamination of ingredients.

    It’s also important to select a cleaner that is compatible with the surface of the equipment you are cleaning. The cleaner manufacturer should be able to guide you and provide compatibility studies for their products.

    Cleaning Method and Location

    Clean-in-place (CIP) or Clean-out-of-place (COP)?

    CIP is generally used for large systems and components that cannot easily be taken apart. CIP often results in less downtime since it eliminates the need to take apart or move the equipment. Automated systems, spray systems and immersion are all examples of CIP operations.

    COP is most often used for smaller pieces of equipment or smaller parts of larger equipment that can be removed and re-assembled after cleaning. COP can involve either manual washing or use of machine washers. Specific instructions for disassembling and re-assembling equipment must be followed.

    What cleaning method will you use?

    Manual, ultrasonic, spray, machine and automated systems are all used for cleaning pharmaceutical equipment. The type of cleaning method used will impact your choice of detergent. Automatic parts cleaners and high-pressure washers require low foaming detergents.

    Temperature

    In most cases, increasing the temperature is one of the best ways to speed up or improve the cleaning action. The temperature parameters that should be used for any individual cleaning application will depend upon the equipment and the soils that are present, as well as your choice of detergent and wash method. Check with the manufacturer for the maximum suggested operating temperature for your detergent.

    Dwell Time

    The length of the cleaning cycle contributes to the effectiveness of your cleaning application. In most cases, a longer dwell time will improve the results. However, all factors – soils, temperature, substrate, detergent and cleaning method must be taken into consideration.

    Rinse Step

    Thorough rinsing should follow cleaning. Rinsing removes any excess detergent left on the item. For critical cleaning applications, it is best to use deionized or distilled water, as rinsing with ordinary water may introduce new contaminants.

    Cleaning Validation

    Cleaning validation is a part of the regulatory compliance process for cleaning pharmaceutical processing equipment. Validation ensures that all equipment is washed according to previously determined standards and that all traces of soil and detergent are removed. Validation methods are unique to each detergent and should be available from most cleaner manufacturers.

    Download IPC’s “7 Step Guide to the Proper Usage of Critical Cleaners” for more information on establishing a cleaning regimen.

    Need help choosing the right specialty cleaner for your pharmaceutical cleaning application? Contact one of International Products Corporation’s (IPC) technical specialists or request a free cleaner sample for testing. All of IPC’s specialty cleaners are registered with NSF as A1 cleaners and can be validated in FDA processes.

  2. How do I Choose the Best Detergent for My Cleaning Application?

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    It’s easy to see that you have a dirty surface that needs to be cleaned. Figuring out what type of cleaner to use can be tricky! Choosing the right product from the outset will make your cleaning task easier, quicker and more efficient. So, how do you know which detergent to use?

    Dirt is Dirt, Right?

    Absolutely not! All soils are different and need to be treated properly. A detergent that works well for cleaning grease and oil might not be the best choice for getting rid of soap scum or starchy soils. While some cleaners may work well for a broad spectrum of soils, others may be needed to target specific types of dirt.

    Alkaline cleaners work well for organic soils like oils and grease, while acid based cleaners are more effective on inorganic soils such metals and salts. Knowing what type of soil you are dealing with is an important step to choosing the right detergent.

    This helpful chart matches detergents to soils commonly found on parts and equipment in laboratories, pharmaceutical plants, food & beverage manufacturing sites, medical devices, filter membranes and manufacturing facilities.

    What are You Cleaning?

    Glass? Metal? Rubber? Electronic parts? Filter membranes? Understanding how different detergents affect different surfaces will certainly have an impact on your choice of cleaner. It’s important to be sure that the detergent you are using is compatible with the surface you are cleaning.

    Many filter membranes are sensitive to harsh chemicals and extreme pH levels, so a cleaner with a mild pH range and safe ingredients may be the right choice. Softer metals and delicate electronic parts may require use of a cleaner with a neutral pH.

    The manufacturer of the cleaner should be able to provide you with compatibility information for the product you are using.

    How are You Cleaning?

    The cleaning method you plan to use also plays a role in choosing a detergent. Some of the more common methods used in manufacturing and laboratory applications include:
    • Ultrasonic cleaning
    • CIP (clean-in place)
    • Manual or hand wash
    • Automatic washers
    It’s important to choose a detergent that works well for your chosen cleaning method. For example, if you are using an automatic washer it’s wise to use a low foaming cleaner. Otherwise you may end up with a room full of foamy suds. While this is great fodder for TV sitcoms, it’s not so funny in real life.

    Is Your Cleaner Safe?

    There are many cleaners on the market that do a great job at removing dirt, but they contain solvents and other harmful ingredients. Look for cleaners that are both effective and safe. Many cleaners are biodegradable. Try to avoid products that contain phosphates, solvents, silicates, phenols, and substances of very high concern.

    International Products Corporation’s (IPC) cleaners are safe for personnel, materials, equipment and the environment. Yet, they are powerful enough to remove the most difficult soils. This makes them excellent alternatives to hazardous solvents and chemicals frequently used for precision cleaning applications.

    The Manufacturer Matters

    When you select a product for your critical cleaning application you should be equally as concerned with the support provided by the manufacturer as you are with the product performance.The benefits of working with an experienced specialty cleaner manufacturer are that they can offer technical guidance and provide a variety of products to best meet your needs. Cleaner manufacturers should be able to assist their customers by providing validation methods, compatibility studies, toxicology reports, regulatory compliance, free product samples, and technical support.

    There are so many variables that exist in choosing the right cleaning product. Remember to consider the soils, the surfaces, the cleaning method, the safety and the manufacturer. With careful thought and planning you can find a cleaner that meets all of your specifications. Choosing wisely makes a difference!

    Download IPC’s ePaper for more information about choosing a cleaner and establishing the right cleaning parameters.

  3. Get The Most Out Of Your Cleaner…Know When To Add More

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    5 Ways To Know When To Change Your Cleaning Solution

    Choosing the best cleaner for your critical cleaning application takes time and careful consideration. With so many choices out there it can be difficult to figure out which cleaner is the best choice for your specific needs. Factors to consider:
    • What is the surface being cleaned?
    • What are the soils?
    • What’s your cleaning method? Manual? CIP? Machine? Ultrasonic?
    • What is the cleaning temperature?
    • Do you need a validation method?
    You’ve done your homework, run trials and have chosen the right cleaner for your cleaning application. Now it’s time to start to clean!

    How much cleaner should I use?
    Determining how much cleaner to use will vary based on the parameters of your unique cleaning application. International Products Corporation (IPC) recommends using a 1% – 2% concentration of their specialty cleaners for most applications. Pouring the water into the tank first, and then adding the detergent, helps to avoid excess foaming when preparing your cleaning solution. The chart below is helpful:

     

    How do I know when it’s time to change the solution?
    For many industrial and critical cleaning applications, it is extremely important to use a consistent cleaning process and keep the cleaning solution at a desired strength. Concentration control methods are procedures used to determine the concentration of a cleaning solution to ensure process consistency. When the concentration of the detergent drops, you know it’s time to change it.

    IPC recommends five methods for testing the cleaning solution to determine the cleaner concentration:
    1. Refractive index
    2. Conductivity
    3. Total alkalinity
    4. Total acidity
    5. Foam height

    Refractive Index
    Refractive index is the “measure of the bending of a ray of light when passing from one medium into another.”¹ A refractometer is used to measure refraction. The refractive index is one way of measuring the amount of a substance in an aqueous solution. A higher refractive index indicates a higher amount of cleaner present in the solution. Conversely, a lower refractive index indicates a lower concentration of cleaner in the solution. If changes to the refractive index are found, it’s time to change your cleaning solution.

    Conductivity
    Conductivity “measures the ability of a given substance to conduct an electric current.”² Conductivity, measured in micro-siemens, can be used to determine the concentration of a cleaning solution. Cleaning solutions have a higher conductivity than water. So, a drop in the level of micro-siemens in your solution is an indication that it’s time to replace it.

    Total Alkalinity
    This method is used for cleaners that are alkaline based (a pH above 7). Total alkalinity measures the ability of a cleaner to neutralize acid. It assesses the cleaning solution’s buffering capacity – its resistance to changes in pH caused by acid. Total alkalinity is tested by performing a titration, a technique where a solution of known concentration is used to determine the unknown concentration of another solution.

    Alkaline builders bind hard water ions, so the surfactants can do their job. Without sufficient alkaline builders, the surfactants would come out of solution and become ineffective.

    If the results show that the pH of your solution has decreased by one full pH unit, it’s a good indication that it’s time to change your cleaning solution.

    Total Acidity
    This method is used for cleaners that are acid based (a pH below 7). Total acidity measures the ability of a cleaner to neutralize alkalinity. Similar to total alkalinity, total acidity is also tested by performing a titration. Changes in the pH of your cleaning solution occur once the soil load capacity of the cleaner has been saturated, indicating it’s time to change the solution.

    Foam Height
    Surfactants in cleaning solutions reduce surface tension, and, as a result, air may become entrapped. This leads to the formation of small bubbles or foam. If the cleaning solution is agitated, either by shaking vigorously by hand or in a blender, a layer of foam will form. The total volume can be measured in a graduated cylinder, and a foam level curve can be created by plotting the known concentration of the detergent versus the measured total volume. If the foam heights of various known concentrations of detergent are calculated, an equation can be created to determine the concentration of future cleaning solutions whose concentration level is unknown.

    All of these methods for calculating the concentration of detergent in a cleaning solution can be converted into simple equations. The data obtained can be plotted on a graph and the slope of the line can be used to calculate the concentration of detergent in your cleaning solution. If you see that the amount of detergent has dropped, you know it’s time to change your cleaning solution.

     

    Need help calculating the concentration of your cleaning solution? IPC’s concentration control methods primer can help. Or contact IPC’s application specialists for assistance.

     

    ¹ https://www.britannica.com/science/refractive-index

    ² http://www.dictionary.com/browse/conductivity

  4. How To Keep Your Tablet Press Clean

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    10 Easy Steps for Cleaning Your Tablet Press

    Nothing can slow production down like equipment that malfunctions or stops working altogether. Performing regular, preventative maintenance of equipment is essential and helps keep pharmaceutical tablet presses functioning efficiently and smoothly.

    Tablet presses that are not well maintained can cause a multitude of problems, creating defective products that are mal-formed, contaminated or contain improper dosages. One of the most important steps to maintaining your tablet press is keeping it clean. It’s also important to have systems in place to validate and document the cleanliness of the equipment.

    10 Key Steps For Cleaning Tablet Presses:

    1. Clean the Exterior: Wipe away all visible dirt on the exterior of the press and vacuum off any excess formulation. Do not use compressed air to blow off excess powders. Compressed air can trap powders in hidden housings, crevices and pockets causing problems down the line.
    2. Visual Inspection: Examine the press to assess the condition of the parts. Look for signs of wear or damage on tablet punches and punch heads, and earmark any parts that need repair or replacement.
    3. Prepare the Press for Cleaning: Carefully dismantle removable machine parts for thorough cleaning. Tooling, punch heads, feed frames, guards and plates can often be removed for cleaning purposes.
    4. Use the Proper Equipment: Stiff nylon punch guide brushes and die seat cleaning tools help to access hidden areas of the press that might contain traces of debris. It’s important not to use any unnecessary force, since tablet presses are delicate and can be easily damaged if not carefully handled.
    5. Choose the Right Cleaner: Your choice of cleaner will depend largely upon the soils that are on your press. Are you removing Oils? Gels? Starches? Enzymes? Use this chart to help match a cleaner to the soil. You’ll also want to consider the surface you are cleaning to be sure you are choosing a compatible cleaner.

    6. Set Up a Proper Cleaning Method: In addition to using the right cleaning product, it’s also important to consider other variables to establish your cleaning protocol. All of the following should be considered:

    a. Amount of Detergent
    b. Temperature
    c. Dwell time
    d. Cleaning method
    e. Type of water

    7. Rinse: Thorough rinsing should follow the cleaning. Rinsing removes any excess detergent left on the item. For critical cleaning applications it is best to use deionized or distilled water, as rinsing with ordinary water may introduce new contaminates.
    8. Validation: Cleaning validation helps identify if there is any remaining residue from soils and cleaners, and helps prevent contamination. Quantitative validation methods, available from most manufacturers, should be used for critical cleaning applications.
    9. Disinfect: If required, disinfection should be done after the press is cleaned and soils are removed.
    10. Dry Parts Thoroughly: Parts should be completely dried to prevent rusting, corrosion or discoloration.

    Setting up an established cleaning routine for your tablet press will help keep it running smoothly and efficiently, and may even extend the serviceable life of your equipment. Regular cleaning will also help prevent regulatory issues and product problems. A few small steps spent on regular cleaning can be a giant leap toward savings and efficiency in the long run.

    For more information on setting up a cleaning regimen and choosing the right cleaner for your application, visit International Products Corporation’s website or contact one of our technical specialists for assistance.

  5. 5 Ways to Keep Your Lab Equipment In Tip-Top Shape for 2018

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    It’s January, the start of a new year and a time when people traditionally promise to make positive changes. Maybe it’s a commitment to exercising or healthy eating, a vow to save money, or maybe even a pledge to stop smoking. Whatever your resolution might be, most of us are in agreement that this is an excellent time of year to start fresh and engage in new behaviors.

    So why not also set a New Year’s resolution for your professional life. The flip of the calendar is an excellent time to establish a regular maintenance plan for your laboratory equipment.

    Just like a car, laboratory equipment must be properly maintained and kept in good working order. Car ownership comes with responsibilities like changing the oil, topping off fluids, rotating tires and washing the vehicle. Performing these actions regularly helps keep your automobile running smoothly, avoiding breakdowns. While no one likes the inconvenience of taking their car in for service, it’s much better than having to call and wait for emergency roadside assistance.

    Likewise, proper maintenance of lab apparatus helps to ensure that your equipment is working correctly and your lab is functioning efficiently. Analyzers, centrifuges and microscopes have to provide accurate readings, and pipettes, beakers, slides and flasks need to be kept clean. Failure to properly maintain lab equipment can have a direct impact on test results.

    5 Steps for Maintaining Lab Equipment:

    1. Inspection
    Inspect equipment on a regular basis. Examining equipment regularly helps discover any irregularities and ensures repairs are made on a timely basis, preventing damages from getting worse. Malfunctioning lab equipment should be repaired at once.
    2. Repair/Refurbish
    Refurbished equipment is completely disassembled and thoroughly cleaned. Some parts are polished and some may need lubrication. Faulty parts can be replaced. The reassembled apparatus frequently works just as well as a brand new piece of equipment.
    3. Calibration
    Keeping your equipment properly calibrated helps increase its accuracy to ensure that data is not corrupted. Inaccurate calibration can result in skewed data.
    4. Clean, Clean, Clean
    Regular cleaning is one of the easiest ways to keep your equipment functioning properly. Apparatus that is not thoroughly cleaned can yield inconsistent results. The exterior surfaces of all equipment should be wiped down on a daily basis, after each use. A complete cleaning should be performed at least once a week. Be sure to take these factors into consideration:

    • Set up a proper cleaning protocol
    • Use the right detergent for each job (this will depend upon the soil and the type of equipment)
    • Rinse thoroughly after cleaning
    • Avoid cross contamination
    • Clean equipment thoroughly prior to disinfecting
    Validate your cleaning process if required

    5. Maintain Safety Standards
    A well-organized lab will run more efficiently. Supplies and chemicals should be clearly labeled and stored. Safety equipment, such as fire extinguishers, showers, first aid kits, and eye wash should be present and well maintained. Lab personnel should be sure to wear protective gear such as gloves, goggles, lab coats and masks. Chemicals should be disposed of properly as instructed on the SDS.

    Properly maintained lab equipment is essential for accuracy and consistency of test results. Investing the time and money to set up and follow a regular maintenance plan will provide long-term savings by keeping your laboratory functioning smoothly and efficiently. This is one New Year’s resolution you’ll certainly want to keep!

    International Products Corporation (IPC) manufactures a full line of specialty cleaners that are excellent for cleaning laboratory equipment. Contact IPC to learn more.

     

  6. The Best of 2017: IPC’s Top 5 Blog Posts of the Year

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    2017 has been a very busy year for International Products Corporation. We launched our new website in March and began publishing our popular blog. Throughout the year we exhibited at various trade shows, visited many of our customers and distributors worldwide, continued our on-site research and development of new products, received a new ISO Standard (ISO 9001:2015) Certification and made some upgrades to our physical plant.

    As the year comes to an end, we want to thank all of our loyal followers and customers for helping to make 2017 a great year.

    Here are our 5 most popular blog posts of the year:

    1. Destroy Dirt…See How Micro-90® Makes Dirt Disappear
    Removing stubborn soils can be challenging. Oil, grease, gels, wax, dyes, flux, emulsifiers and biological debris are just some of the soils that are difficult to get rid of. It can be a daunting task to find a cleaner powerful enough to remove these soils, and is also non-hazardous and environmentally friendly

    2. Which P-80® Lubricant Is The Right Choice For My Job?
    Emulsion? THIX? Grip-It? RediLube? … What’s the Difference? All P-80 products provide temporary lubrication needed to reduce friction during rubber assembly to make it easier to install parts. Since each assembly application is unique, IPC has developed different P-80 formulas so workers can choose the product that will work best for their particular application

    3. A Picture is Worth a Thousand Words… Explore and Learn with IPC’s Video Library!
    “A picture is worth a thousand words.” We’ve all heard this saying many times throughout our lives. Basically, it refers to the notion that an image can convey an idea much more succinctly than words. A beautiful sunset, a smiling baby, a championship team celebrating victory…the images each of these moments convey are much more powerful than their descriptions

    4. Formulated Cleaners…The Best Recipe For Safe, Powerful Cleaning!
    What makes one cleaning product different from another? Aren’t they all the same? You may be surprised to learn that there are many different types of cleaners, each designed for varying purposes. Choosing the right cleaner for the job isn’t a “one size fits all” proposition, but rather a well thought out process in which many factors must be considered

    5. Stop Struggling … See How Temporary Lubricants Make Rubber Assembly Easier!
    Have you ever struggled with rubber assembly? If so, you’ve probably experienced for yourself the excessive force needed to properly install hoses, seals, gaskets, O-rings and many other rubber parts. Wouldn’t it be nice if someone came up with a better way?

    Did we miss your favorite post from 2017? Please let us know! We have more great content coming your way in 2018. Be sure to subscribe to the IPC blog to read the latest and greatest from the IPC team.

    Happy New Year and Best Wishes for a wonderful 2018 from everyone at IPC!

  7. Is Your Cleaner Biodegradable?

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    When it comes time to choose a product for critical cleaning applications most of us are concerned with performance. We want a powerful cleaner that will remove all soils and get the job done. But, have you ever stopped to wonder about the environmental effects of that product?

    What if you found a powerful, effective cleaner that was also environmentally friendly and safe for all personnel? What if the cleaner was actually biodegradable? Do these products exist? Can you find a safe precision cleaner that delivers the exceptional performance you’re seeking?

    International Products Corporation (IPC) manufactures a full line of specially formulated precision cleaners that are among the safest yet most effective solutions on the market. All of IPC’s environmentally safe cleaners are free of solvents, phosphates, silicates, phenols, and substances of very high concern.

    IPC’s cleaners are safe for personnel, materials and equipment, and the environment. Yet, they are powerful enough to remove the most difficult soils. This makes them excellent alternatives to hazardous solvents and chemicals frequently used for precision cleaning applications.

    Choose from 3 different biodegradable cleaners

    • Micro® Green Clean is an industrial-strength, free-rinsing, multi-purpose hard surface cleaner designed for use in a wide range of cleaning applications. Target soils include grease, oil and biological debris. It is excellent for cleaning metals, ceramics, medical instruments, food-processing equipment, filter membranes, and other surfaces.
    • Micro® A07 is a powerful blend of chelating citric acid and anionic surfactants designed to remove salts, soap scum, metal oxides, hard water scale, grease, rust, milkstone, mineral deposits and inorganic material from filter membranes, labware, and industrial equipment.
    • Zymit® Pro is a neutral-pH cleaner formulated with a unique blend of protease enzymes, surfactants, and builders that work together to remove tough protein-based soils. The enzymes dissolve the soils, and the detergents help lift and wash them away. Target soils include food, gelatin, and biological materials such as blood, fat, and tissue. Zymit® Pro is effective for cleaning filter membranes, metals, ceramics, plastics, medical instruments and devices, food processing equipment, and other surfaces.

    When cleanliness counts, you can count on IPC’s full line of specialty cleaners. IPC’s mild, yet powerful precision cleaners destroy dirt and help keep workers and the environment safe. Registered with the NSF as USDA A1 cleaners, IPC’s precision cleaners are effective for cleaning a broad spectrum of soils from all types of surfaces and have helped companies in the most highly regulated industries solve their cleaning challenges.

    What’s in your plant? Replace traditionally used corrosives, phosphates, solvents, petroleum distillates, and other hazardous chemicals with safe yet powerful precision cleaners. Learn more here or contact IPC’s technical team for help with choosing the right solution for your cleaning application.

  8. Destroy Dirt…See How Micro-90® Makes Dirt Disappear

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    Removing stubborn soils can be challenging. Oil, grease, gels, wax, dyes, flux, emulsifiers and biological debris are just some of the soils that are difficult to get rid of. It can be a daunting task to find a cleaner powerful enough to remove these soils, and is also non-hazardous and environmentally friendly.

    Enter Micro-90®
    Micro-90 is a mild, yet powerful, multi-purpose, formulated cleaner that is effective in both industrial and critical cleaning applications. This unique detergent contains chelants and anionic and nonionic ingredients which combine to produce a variety of cleaning actions. Micro-90 lifts, disperses, emulsifies, sequesters, suspends, and decomposes soils. Once rinsed away, surfaces are thoroughly clean without any residue.

    Micro-90 is designed for a wide range of applications. It can be used to remove oil, grease, resin, tar, wax, biological material, insoluble oxides, gels, dyes, fine particles, flux, emulsifiers and many other soils. Micro-90 is excellent at cleaning metal, glass, ceramic, rubber, plastic, gemstones, filter membranes and most other hard surfaces.

    Seeing is Believing
    International Products Corporation (IPC), the manufacturer of Micro-90, demonstrates the effectiveness of Micro-90 in this video.

    m90-wipe

    In the video you can watch as Micro-90 removes heavy soil build-up from ceramic tiles and metal surfaces. Soils shown in this example include simulated bathroom grease and oil, baked on kitchen grease and mineral-based soils. A 2% concentration of Micro-90 in water is all that is needed to remove dirt and restore cleanliness to surfaces. You can actually watch dirt lifting off the objects and when finished, they look just like new!

    7 Reasons You Should Use Micro-90 Concentrated Cleaning Solution:

    • 7-Way Action – Lifts, disperses, emulsifies, sequesters, dissolves, suspends and decomposes soils
    • Manufactured in a dedicated system and lot number controlled
    • Fast, effective soil removal
    • Environmentally Friendly – Free of solvents, phosphates, silicates, phenols and Substances of Very High Concern
    • NSF-Registered, USDA-A1 Cleaner
    • Sample Validation Methods are available for FDA regulated processes
    • Economical – Highly concentrated, easy to use liquid

    See for yourself! Request a free sample and put Micro-90 to the test for your most challenging cleaning applications.

    Interested in learning more about Micro-90? Visit IPC’s website or contact one of our technical specialists.

  9. Make Your Membranes Last…A Simple 10 Step Guide

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    What Are Membranes?
    Membranes are filters used to separate different substances. They are used for a variety of applications throughout many industries, including wastewater treatment, food & beverage processing, pharmaceutical manufacturing and laboratory operations. “A membrane is a thin layer of semi-permeable material that separates substances when a driving force is applied across the membrane. Membrane processes are increasingly used for removal of bacteria, microorganisms, particulates, and natural organic material…”  (https://www.mrwa.com/WaterWorksMnl/Chapter%2019%20Membrane%20Filtration.pdf)

    Why Clean Membranes?
    Once membranes become fouled from use they become less effective. Clean membranes allow for the proper flow of water and are essential for maintaining an optimal flux rate. Therefore, it is important to implement a regular membrane cleaning regimen to help ensure that they are operating effectively. Instituting a regular maintenance program for cleaning membranes can help extend membrane life, saving money on equipment and operating costs.

    Where Do I Begin?
    Establishing a regular membrane cleaning regimen can be overwhelming. There are so many variables to consider from choosing the right detergent to figuring how much cleaner to use and how often to clean.

    Follow this simple 10 step guide to get started:

    1. When should I clean membranes?
    Use a 10/10/10 rule to determine cleaning frequency. Membranes should be cleaned whenever flux rate decreases by 10%, trans-membrane pressure (TMP) increases by 10%, or permeate water quality decreases by 10%.

    2. What cleaner should I use?
    Using the proper detergent can greatly affect the outcome. The soils fouling the membranes directly impact your choice of cleaner. Read more here.

    3. What type of membranes are you using?
    It’s always important to check with the membrane manufacturer for any specific operating conditions.

    4. Should I soak before cleaning?
    This will depend upon the condition of the membranes. An initial soak may be required if membranes are extremely fouled.

    5. How much cleaner do I use?
    The amount of cleaner used will vary based upon which detergent you are using and upon the parameters of your membrane system. Fill equipment up to 50% of its total volume to provide low pressure and high flux for optimal cleaning. The manufacturer of the cleaner should be able to provide specific guidelines.

    6. Should I use a quick or slow flow rate?
    Start with a slow flow rate to prevent any suspended soils from re-fouling the membranes. Then, gradually increase the flow up to its maximum rate.

    7. Do I recirculate?
    This helps to effectively clean the membrane. Recirculating provides agitation in and around the membrane. Air bubbles are introduced from recirculation, creating a turbulent flow. This turbulence causes a subtle, pulsating change in pressure at the membrane surface that assists in dislodging foulants. Recirculation may also increase the temperature of the cleaning solution by a few degrees, which bolsters detergency.

    8. What’s the proper temperature?
    As with any cleaning application, heating the cleaning solution will improve results. Check manufacturer’s guidelines for maximum operating temperatures for both the membranes and the cleaners.

    9. Do I need to rinse?
    A thorough rinsing step is important to make sure that all of the soils, as well as any excess cleaning solution, have been removed from the system.

    10. Can I set it and forget it?
    Absolutely not! It’s important to monitor the process to check for any abnormalities or changes in temperature, pressure or pH. However, using a safe and compatible cleaner allows more forgiveness in the cleaning regimen if operator error is introduced.

    Make Your Membranes Last
    Cleaning membranes on a regular basis restores membrane flux which aids in prolonging membrane life. Membranes are extremely expensive. Keeping them clean and functioning optimally saves money.

    When selecting a membrane cleaner find a manufacturer that provides a range of proven products and offers free technical support, free product samples, customer referrals and on-site assistance. International Products Corporation (IPC) offers a full line of membrane cleaners that have been proven to restore 100% membrane flux and extend membrane life.

    One of IPC’s customers treats industrial wastewater generated by the engine plant of a major automotive manufacturer. At this facility, up to 168,000 gallons of wastewater are treated per day using an ultrafiltration (UF) membrane system. They have used IPC’s Micro-90® Concentrated Cleaning Solution to clean their membranes for over 14 years with 100% flux recovery. Prior to using Micro-90®, their initial two-step process used caustic materials and acids. A 1% solution of Micro-90® not only removes the organics and metals that blind the membranes, but it provides savings through reduced energy, reduced chemical use and less downtime. They did not need to replace any of their membranes for over 14 years, representing a cost savings of over $500,000.

    Download IPC’s CIP Guidelines for Membrane Cleaning for help in setting up a membrane cleaning regimen. Establishing a regular cleaning schedule for your membranes can add years to their life!

     

  10. How To Choose the Proper Membrane Cleaner

    Comments Off on How To Choose the Proper Membrane Cleaner

    Cleaning filter membranes is a challenge faced by water treatment facilities across a variety of industries. In addition to municipal water treatment plants, wastewater treatment occurs in the automotive, metalworking, food & beverage, textile, parts cleaning, oil & gas, pharmaceutical, industrial manufacturing, and electronics industries. Keeping filter membranes clean is a concern to all of them.

    Once membranes become fouled from use they become less effective. Clean membranes allow for the proper flow of water. Keeping membranes clean is essential to maintaining an optimal flux rate and helps ensure that the treatment plant is operating effectively. Therefore, it is important to implement a regular membrane cleaning regimen.

    Finding the right membrane cleaner for the job can be a challenge. Using the right membrane cleaner is a good economic decision as it minimizes downtime and prolongs membrane life. Since membranes are extremely expensive, most facilities try their best to keep them operational for as long as possible.

    What should treatment plant operators seek in a membrane cleaner?

    • Cleaners should restore membrane flux. This will help prolong the life of the membrane.
    • Products that will reduce the cleaning frequency needed. This will lead to reduced down time and lower costs for cleaning products.
    • Cleaners that are safe for the membranes and the environment.
    • Products that are easy to use.

    Many membranes are sensitive to harsh chemicals and extreme pH levels. It is important for treatment plant operators to choose cleaners that will not be harmful to the membranes. Many specialty cleaners with mild pH ranges and safe ingredients are formulated to be effective, non-harmful cleaning agents for membranes.

    What types of soils are present?

    Different types of soils require different types of treatment. Plant operators must also consider the type of soil found in the water that is being treated.

    Alkaline cleaners dissolve oils and greases. These types of soils are often found in industrial manufacturing facilities. An alkaline cleaner that also contains chelants can suspend metals and minerals to restore membrane flux.

    Acid based cleaners are excellent at dissolving scale, like calcium carbonate or iron oxide. But, many acid cleaners, such as sulfuric, hydrochloric, and phosphoric, are hazardous. Citric acid cleaners are much safer and have a broader range of filter compatibilities. Citric acid cleaners that also contain surfactants can go after many oils and greases that might be present in addition to scale.

    In the food processing industry, soils may contain proteins and starches. Enzymatic cleaners are an excellent choice for targeting these soils.

    Most foulants are combinations of various soils. Choosing a formulated cleaner with multifunctional ingredients is usually the best solution.

    There are so many variables that can exist in choosing the right cleaning product for each facility. Treatment plant operators can benefit greatly from working with specialty cleaner manufacturers that can offer them technical guidance and provide them with a variety of products to best meet their needs. When selecting a membrane cleaner find a company that provides a range of proven products and offers free technical support, free product samples, customer referrals and on-site assistance.

    Read this article about how one municipal treatment plant keeps their membranes clean and functional.

    More information about membrane cleaning can be found on International Products Corporation’s website. Contact our technical specialists for assistance in choosing the right membrane cleaner for your operation.

Detergent Selection Guide

= Used ; = Preferred
SOILS Micro-90® Micro® Green Clean Micro® A07 Surface-Cleanse/930® LF2100® Zymit® Low-Foam Zymit® Pro
Adhesives
Biofilm
Biological soils: Blood, Feces, Mucous, Sebum, Sweat, Urine
Dyes, Inks
Eggs, Butter, Fruit Stains
Emulsifiers
Fat
Fingerprints
Flavor, Fragrances
Gelatin
Gels
Grass
Insoluble Salts
Milkstone
Oils
Oxides
Paraffins
Petrolatum
Proteins
Scale
Shop Dusts, Soldering Flux
Silicons
Starch
Tar
Tissue
Titanium Dioxides